A 60-year-old man with recent aortic valve replacement develops endocarditis at 6 weeks post-surgery. Blood cultures grow Staphylococcus epidermidis

Question

A 60-year-old man with recent aortic valve replacement develops endocarditis at 6 weeks post-surgery. Blood cultures grow Staphylococcus epidermidis (methicillin-resistant, Vancomycin MIC 1 mg/L, Rifampicin-sensitive, Gentamicin-sensitive). What is the standard antibiotic regimen and duration?

Accepted Answer

IV Vancomycin for ≥6 weeks plus oral Rifampicin for ≥6 weeks plus IV Gentamicin for the first 2 weeks

Answer

IV Daptomycin for 6 weeks as the preferred next management strategy in this patient

Answer

IV Vancomycin alone for 4 weeks as the preferred next management strategy in this patient

Answer

Oral Rifampicin alone for 6 months as the preferred next management strategy in this patient

Answer

IV Flucloxacillin for 6 weeks as the preferred next management strategy in this patient

Prosthetic Valve Endocarditis — SCE Infectious Diseases MCQ

A 60-year-old man with recent aortic valve replacement develops endocarditis at 6 weeks post-surgery. Blood cultures grow Staphylococcus epidermidis (methicillin-resistant, Vancomycin MIC 1 mg/L, Rifampicin-sensitive, Gentamicin-sensitive). What is the standard antibiotic regimen and duration?