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HBV Post-Exposure Prophylaxis — SCE Infectious Diseases MCQ

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HardInfection Prevention & ControlHBV Post-Exposure ProphylaxisSCE Infectious Diseases

A vaccinated healthcare worker sustains a needlestick from a highly infectious hepatitis-B source. A documented post-vaccination anti-HBs result is 350 mIU/mL. What hepatitis-B post-exposure action is required?

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Correct answer: C — No hepatitis-B vaccine booster or immunoglobulin is required for this documented responder

The best answer is “No hepatitis-B vaccine booster or immunoglobulin is required for this documented responder”. A documented vaccine responder has protective antibody far above the response threshold; the exposure is still reported and assessed for other blood-borne viruses, but HBV PEP is unnecessary. Hepatitis-B post-exposure management depends on source infectivity, documented vaccine response and whether the exposed person is a known responder.

Reference: UK Health Security Agency Green Book: hepatitis B: https://www.gov.uk/government/publications/hepatitis-b-the-green-book-chapter-18