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Adenovirus in HSCT — SCE Infectious Diseases MCQ

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HardImmunocompromised HostAdenovirus in HSCTSCE Infectious Diseases

After allogeneic stem-cell transplantation, a patient develops high-level adenovirus DNAaemia with diarrhoea and hepatitis. What management principle is most appropriate?

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Correct answer: D — Reduce immunosuppression where feasible and consider cidofovir

The best answer is “Reduce immunosuppression where feasible and consider cidofovir”. Immune recovery is central to control, while cidofovir may be used for significant disease despite toxicity and limited trial evidence; decisions must balance graft-versus-host disease risk. Post-transplant infection management combines organism-directed supportive care with careful immunosuppression review because impaired cellular immunity can prolong viral shedding and disease.

Reference: Review of viral enteritis and systemic viral infection after transplantation: https://pmc.ncbi.nlm.nih.gov/articles/PMC7149989/