skip to main content

Invasive Aspergillosis in CGD — SCE Infectious Diseases MCQ

Instant feedback + full explanation. One question, done properly.

HardImmunocompromised HostInvasive Aspergillosis in CGDSCE Infectious Diseases

A man with chronic granulomatous disease develops proven invasive pulmonary aspergillosis while taking itraconazole prophylaxis. Susceptibility is pending and there is no contraindication to triazoles. Which initial treatment is most appropriate?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Start IV voriconazole with therapeutic exposure and interaction review

CGD strongly predisposes to invasive mould infection but does not create a separate rule excluding standard active therapy. Voriconazole is licensed first-line treatment for invasive aspergillosis. Breakthrough infection requires urgent treatment plus susceptibility, exposure and interaction review rather than simply increasing prophylaxis.

Reference: Voriconazole 200 mg infusion SmPC. https://www.medicines.org.uk/emc/product/101208/smpc