skip to main content

Guillain-Barré Syndrome — SCE Infectious Diseases MCQ

Instant feedback + full explanation. One question, done properly.

ModerateCNS InfectionGuillain-Barré SyndromeSCE Infectious Diseases

A 26-year-old woman with no significant medical history presents with acute onset of ascending flaccid paralysis, areflexia, and respiratory compromise over 48 hours. She had a respiratory tract infection 2 weeks ago. Nerve conduction studies show an acute inflammatory demyelinating polyneuropathy (AIDP) pattern. CSF shows raised protein with normal cell count (albuminocytological dissociation). What is the most appropriate treatment?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — IV Immunoglobulin (IVIG) 0.4 g/kg daily for 5 days

Guillain-Barré syndrome (AIDP variant) with respiratory compromise requires urgent treatment. IVIG (0.4 g/kg/day for 5 days) and plasma exchange are equally effective first-line treatments; IVIG is more commonly used in UK practice due to practicality. They should not be used sequentially as there is no added benefit. Corticosteroids are not effective for GBS. The key post-infectious triggers include Campylobacter jejuni (~30%), CMV, EBV, and Mycoplasma pneumoniae. Respiratory monitoring (FVC) is critical — intubation may be needed if FVC <20 mL/kg.

Reference: NICE NG220 2022 – Guillain-Barré syndrome