Buruli Ulcer — SCE Infectious Diseases MCQ

Correct answer: D — Use an 8-week rifampicin-based combination regimen, commonly rifampicin plus clarithromycin, with wound and reconstructive care as required with review

The best answer is “Use an 8-week rifampicin-based combination regimen, commonly rifampicin plus clarithromycin, with wound and reconstructive care as required with review”. Buruli ulcer is treated with a defined rifampicin-based combination; surgery and rehabilitation complement rather than replace antimicrobial therapy. “Use standard RHZE tuberculosis treatment for 6 months” is less appropriate because it conflicts with the decisive clinical feature or cited guidance. “Use clarithromycin monotherapy for 2 weeks” is less appropriate because it conflicts with the decisive clinical feature or cited guidance. “Use surgery alone without antimicrobials” is less appropriate because it conflicts with the decisive clinical feature or cited guidance. “Use dapsone and rifampicin for 12 months as multibacillary leprosy” is less appropriate because it conflicts with the decisive clinical feature or cited guidance.

Reference: WHO Buruli ulcer fact sheet: https://www.who.int/news-room/fact-sheets/detail/buruli-ulcer-(mycobacterium-ulcerans-infection)