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Malaria Prophylaxis — SCE Infectious Diseases MCQ

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HardTravel Medicine & VaccinationMalaria ProphylaxisSCE Infectious Diseases

A traveller taking sertraline needs malaria chemoprophylaxis for a destination where several options are effective and has a history of depression. Which option usually has the most favourable neuropsychiatric profile?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Atovaquone–proguanil after destination, renal function and interaction checks

The best answer is “Atovaquone–proguanil after destination, renal function and interaction checks”. Mefloquine is unsuitable with significant psychiatric history; atovaquone–proguanil is generally well tolerated when the itinerary and renal function permit it. Malaria chemoprophylaxis is selected by destination, resistance, contraindications, interactions, pregnancy and previous neuropsychiatric adverse effects.

Reference: UK malaria prevention guidelines for travellers: https://www.gov.uk/government/publications/malaria-prevention-guidelines-for-travellers-from-the-uk