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Hepatitis C — SCE Infectious Diseases MCQ

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HardHepatitisHepatitis CSCE Infectious Diseases

A man with suppressed HIV on dolutegravir/tenofovir alafenamide/emtricitabine has untreated genotype 4 HCV, no cirrhosis and normal renal function. Which pangenotypic course is appropriate after interaction review?

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Correct answer: E — Sofosbuvir/velpatasvir once daily for 12 weeks

Sofosbuvir/velpatasvir is pangenotypic and the authorised regimen for adults without decompensated cirrhosis is 12 weeks. HIV coinfection does not require extending this regimen when interactions and organ function are suitable. Interferon-based and prolonged ribavirin regimens are obsolete for this presentation.

Reference: Sofosbuvir/velpatasvir 400/100 mg SmPC. https://www.medicines.org.uk/emc/product/7294/smpc