Yellow Fever Vaccination — SCE Infectious Diseases MCQ

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EasyTravel Medicine & VaccinationYellow Fever VaccinationSCE Infectious Diseases

A 30-year-old man with well-controlled HIV (CD4 480, VL <50) is planning travel to a yellow fever endemic area. Can he receive the yellow fever vaccine?

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Correct answer: A — Yes; live vaccines including yellow fever can be given if CD4 >200 cells/µL and VL suppressed

Yellow fever vaccine (a live attenuated vaccine) can be given to people living with HIV if CD4 count is ≥200 cells/µL (BHIVA vaccination guidelines). The vaccine is contraindicated if CD4 <200 cells/µL due to risk of vaccine-associated viscerotropic disease. With a CD4 of 480 and suppressed viral load, this patient can safely receive the vaccine. Seroconversion rates may be slightly lower in PLWH, and booster consideration may be needed.

Reference: BHIVA 2024 – Vaccination guidelines for adults with HIV; UKHSA 2024 – Green Book Chapter 35: Yellow Fever