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Latent TB — SCE Infectious Diseases MCQ

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HardTuberculosisLatent TBSCE Infectious Diseases

A person newly diagnosed with HIV has positive IGRA, normal chest imaging and no symptoms. Active tuberculosis is excluded and drug interactions permit a rifamycin. Which latent-TB regimen is appropriate?

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Correct answer: B — Isoniazid plus rifampicin daily for 3 months with pyridoxine when indicated

The best answer is “Isoniazid plus rifampicin daily for 3 months with pyridoxine when indicated”. HIV increases progression risk, so latent infection is treated after active disease is excluded; the short 3HR course is suitable when ART interactions and hepatotoxicity are addressed. NICE specifies UK testing, latent-infection treatment and drug-susceptible tuberculosis regimens. BHIVA guidance governs investigation and treatment of HIV-associated disease and supports standard specialist care when HIV is virologically controlled.

Reference: NICE NG33: tuberculosis: https://www.nice.org.uk/guidance/ng33/chapter/Recommendations BHIVA clinical guidelines: https://bhiva.org/clinical-guidelines/