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VRE Bacteraemia — SCE Infectious Diseases MCQ

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HardHealthcare-Associated InfectionsVRE BacteraemiaSCE Infectious Diseases

A hospital laboratory identifies a vancomycin-resistant Enterococcus faecium (VRE) from a blood culture. The patient is on the haematology ward with febrile neutropenia. The organism is resistant to Vancomycin (MIC >256 mg/L) and Ampicillin. What is the most appropriate treatment?

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Correct answer: E — Daptomycin 8–10 mg/kg IV daily

High-dose daptomycin is a UK specialist option for vancomycin-resistant E. faecium bloodstream infection, guided by susceptibility, source control and endocarditis assessment. Monitor creatine kinase, renal function and interacting statins. Linezolid is an alternative in selected cases but is bacteriostatic and limited by marrow toxicity.

Reference: https://bnf.nice.org.uk/drugs/daptomycin/