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Latent TB — SCE Infectious Diseases MCQ

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HardTuberculosisLatent TBSCE Infectious Diseases

An immunocompetent adult has latent tuberculosis, normal liver function and no important rifamycin interaction. Active disease has been excluded. Which short UK regimen is appropriate?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Isoniazid plus rifampicin daily for 3 months with pyridoxine when indicated

The best answer is “Isoniazid plus rifampicin daily for 3 months with pyridoxine when indicated”. NICE offers three months of isoniazid plus rifampicin as a shorter latent-infection regimen when interactions and hepatotoxicity risks are acceptable; six months of isoniazid is an alternative in selected patients. NICE specifies UK testing, latent-infection treatment and drug-susceptible tuberculosis regimens.

Reference: NICE NG33: tuberculosis: https://www.nice.org.uk/guidance/ng33/chapter/Recommendations