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Brucellosis — SCE Infectious Diseases MCQ

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HardTropical & Imported InfectionsBrucellosisSCE Infectious Diseases

A livestock worker has culture-confirmed Brucella melitensis infection with MRI-proven sacroiliitis. Which antimicrobial principle is appropriate?

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Reveal the answer and explanation

Correct answer: E — Prolonged doxycycline–rifampicin combination therapy

The best answer is “Prolonged doxycycline–rifampicin combination therapy”. Brucella is intracellular and relapses after inadequate monotherapy; focal osteoarticular infection requires at least a standard six-week combination and often longer specialist-directed treatment. Brucellosis is a zoonosis causing undulant fever and focal osteoarticular disease; combination therapy reduces relapse and duration is extended for focal infection.

Reference: WHO brucellosis fact sheet and technical guidance: https://www.who.int/news-room/fact-sheets/detail/brucellosis