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HIV — SCE Infectious Diseases MCQ

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ModerateHIV MedicineHIVSCE Infectious Diseases

A 28-year-old woman living with HIV is now 10 weeks pregnant. She is ART-naive and has a CD4 count of 410 cells/µL with a viral load of 45,000 copies/mL. HBsAg is negative. What is the recommended antiretroviral regimen?

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Correct answer: D — Tenofovir Disoproxil/Emtricitabine/Dolutegravir

BHIVA 2025 pregnancy guidelines recommend commencing triple ART immediately with Tenofovir DF/Emtricitabine plus Dolutegravir 50 mg as the preferred regimen. Tenofovir DF is preferred over Tenofovir AF in pregnancy as the backbone NRTI due to greater pregnancy safety data, though TAF is an acceptable alternative. Dolutegravir is now the preferred integrase inhibitor in pregnancy following reassuring safety data regarding neural tube defects.

Reference: BHIVA 2025 – Guidelines on the management of HIV in pregnancy and the postpartum period