A 30-year-old woman with Eisenmenger syndrome secondary to a large VSD is reviewed. Her resting oxygen saturations are 82% on room air. She reports

Question

A 30-year-old woman with Eisenmenger syndrome secondary to a large VSD is reviewed. Her resting oxygen saturations are 82% on room air. She reports worsening exercise tolerance. Which class of pulmonary vasodilator has the strongest evidence for improving exercise capacity in Eisenmenger syndrome?

Accepted Answer

Endothelin receptor antagonists (e.g. bosentan)

Answer

Phosphodiesterase type 5 inhibitors (e.g. sildenafil)

Answer

Prostacyclin analogues (e.g. epoprostenol)

Answer

Calcium channel blockers (e.g. nifedipine)

Answer

Soluble guanylate cyclase stimulators (e.g. riociguat)

Eisenmenger Syndrome — EECC MCQ

A 30-year-old woman with Eisenmenger syndrome secondary to a large VSD is reviewed. Her resting oxygen saturations are 82% on room air. She reports worsening exercise tolerance. Which class of pulmonary vasodilator has the strongest evidence for improving exercise capacity in Eisenmenger syndrome?