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RAAS Inhibitor Renal Effects — EECC MCQ

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HardHeart FailureRAAS Inhibitor Renal EffectsEECC

Two weeks after starting ramipril for HFrEF, creatinine rises from 110 to 145 micromol/L and potassium is 5.4 mmol/L. The patient is euvolaemic and takes ibuprofen. What is the best next step?

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Correct answer: ARemove reversible causes, adjust ramipril and repeat bloods

The creatinine rise is about 32%, exceeding the commonly accepted 30% trigger for reassessment, and potassium is also elevated. NSAID use is a reversible contributor. The appropriate response is prompt medication and volume review, removal of nephrotoxins, dose adjustment or temporary withholding as clinically indicated, and repeat testing—not automatic permanent loss of prognostic therapy or unmonitored continuation. Apply this conclusion only to the clinical circumstances stated, with appropriate specialist review, contraindication checks, shared decision-making and follow-up. Reassess if the physiology, treatment response or competing risk changes. The competing options would require a different haemodynamic profile, diagnosis, procedural indication or risk balance from the one described here.

Reference: NICE NG106: chronic heart failure in adults. https://www.nice.org.uk/guidance/ng106/chapter/recommendations