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Exercise Restriction in Pericarditis — EECC MCQ

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HardPericardial DiseaseExercise Restriction in PericarditisEECC

A teenager with catecholaminergic polymorphic ventricular tachycardia continues to develop bidirectional VT on exercise despite a maximally tolerated non-selective beta-blocker. What is the next pharmacological step?

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Correct answer: DAdd flecainide to continued nadolol with repeat exercise-provocation testing

Flecainide is added to a maximally tolerated non-selective beta-blocker when exercise-provoked ventricular arrhythmia persists, with repeat exercise or catecholamine provocation used to assess suppression. Verapamil monotherapy abandons preferred beta-blockade; adding sotalol to nadolol is not the evidence-based adjunct and adds QT and renal-dose risk; adding amiodarone adds substantial extracardiac toxicity without equivalent CPVT evidence; and increasing nadolol above the tolerated dose is unsafe. Digoxin does not suppress CPVT ectopy and may increase arrhythmic risk.

Reference: 2022 ESC Guidelines for ventricular arrhythmias and sudden cardiac death. https://academic.oup.com/eurheartj/article/43/40/3997/6675633