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Palliative Inotrope Infusions — SCE Palliative Medicine MCQ

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HardNon-Malignant Palliative CarePalliative Inotrope InfusionsSCE Palliative Medicine

A 68-year‑old woman with end‑stage heart failure has been on optimal guideline‑directed medical therapy for 10 years. She is now NYHA IV with EF 10%. She asks about palliative inotrope infusions. What does current evidence support regarding palliative milrinone or dobutamine?

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Correct answer: BPalliative inotrope infusions can improve symptoms (breathlessness, fatigue) and facilitate home‑based care, but do not extend survival and carry risks such as arrhythmias or sudden death; they should be considered as part of a symptom‑focused palliative approach

Explanation lettering: B = shown as A · E = shown as B · D = shown as C · C = shown as D · A = shown as E

Option E is correct. Systematic review data show that ambulatory inotrope infusions (e.g., milrinone or dobutamine) improve NYHA functional class and symptom burden without improving survival ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30007556/?utm_source=openai)). Small observational studies of home dobutamine likewise demonstrate symptomatic relief and reduced hospitalisations but no survival benefit ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/29341466/?utm_source=openai)). Risks—including arrhythmias and potential sudden death—are well recognised. Options A, B, C and D are contradicted by the evidence.

Reference: Ambulatory Inotrope Infusions in Advanced Heart Failure: A Systematic Review and Meta‑Analysis, JACC Heart Failure, 2018. https://pubmed.ncbi.nlm.nih.gov/30007556/