A 71-year-old man with newly diagnosed Parkinson's disease asks about long-term motor complications of Levodopa. What is the MOST accurate explanation...

Question

A 71-year-old man with newly diagnosed Parkinson's disease asks about long-term motor complications of Levodopa. What is the MOST accurate explanation of the on-off phenomenon?

Accepted Answer

Unpredictable, sudden, random switching between periods of good motor function and periods of immobility, unrelated to dose timing

Answer

Predictable end-of-dose wearing off at regular intervals

Answer

Fluctuations in mood only

Answer

Alternating between sleep and wakefulness

Answer

Periodic limb movements during sleep

uk-dgm MCQ (SBA): On-Off Phenomenon vs Wearing Off

A 71-year-old man with newly diagnosed Parkinson's disease asks about long-term motor complications of Levodopa. What is the MOST accurate explanation of the on-off phenomenon?