A 42-year-old man with recurrent major depressive disorder has had an adequate 8-week trial of an SSRI at therapeutic dose with minimal improvement. A...

Question

A 42-year-old man with recurrent major depressive disorder has had an adequate 8-week trial of an SSRI at therapeutic dose with minimal improvement. According to updated CANMAT depression guidelines, what is the next most appropriate step?

Accepted Answer

Switch to or augment with another evidence-based antidepressant

Answer

Stop the SSRI and start a benzodiazepine alone

Answer

Increase SSRI dose above recommended maximum

Answer

Add an antipsychotic as first augmentation strategy in primary care

Answer

Continue the same regimen for another 6 months before changing

ca-mccqe1 MCQ (SBA): Treatment-resistant major depressive disorder

A 42-year-old man with recurrent major depressive disorder has had an adequate 8-week trial of an SSRI at therapeutic dose with minimal improvement. According to updated CANMAT depression guidelines, what is the next most appropriate step?