A 48-year-old woman presents with diarrhoea, weight loss and iron deficiency anaemia. Coeliac serology shows markedly elevated tissue transglutaminase...

Question

A 48-year-old woman presents with diarrhoea, weight loss and iron deficiency anaemia. Coeliac serology shows markedly elevated tissue transglutaminase IgA. Total IgA is normal. Which is the most appropriate next step to confirm the diagnosis?

Accepted Answer

Upper gastrointestinal endoscopy with duodenal biopsies while she remains on a gluten-containing diet

Answer

Start a strict gluten-free diet immediately without further testing

Answer

HLA typing only

Answer

Small bowel MRI

Answer

Capsule endoscopy

au-racgp MCQ (SBA): Coeliac disease diagnosis

A 48-year-old woman presents with diarrhoea, weight loss and iron deficiency anaemia. Coeliac serology shows markedly elevated tissue transglutaminase IgA. Total IgA is normal. Which is the most appropriate next step to confirm the diagnosis?