A 28-year-old woman with known systemic lupus erythematosus develops proteinuria and rising creatinine. Renal biopsy confirms proliferative lupus neph...

Question

A 28-year-old woman with known systemic lupus erythematosus develops proteinuria and rising creatinine. Renal biopsy confirms proliferative lupus nephritis. What is the most appropriate management?

Accepted Answer

Immunosuppressive therapy with glucocorticoids plus mycophenolate or cyclophosphamide

Answer

No change to current hydroxychloroquine therapy

Answer

High-dose glucocorticoids alone without other agents

Answer

NSAIDs alone

Answer

Immediate dialysis without immunosuppression

au-racp MCQ (SBA): Lupus nephritis

A 28-year-old woman with known systemic lupus erythematosus develops proteinuria and rising creatinine. Renal biopsy confirms proliferative lupus nephritis. What is the most appropriate management?