A 28-year-old woman presents with persistent low mood, anhedonia, and impaired functioning for 8 weeks. There is no bipolar history, psychosis, or sub...

Question

A 28-year-old woman presents with persistent low mood, anhedonia, and impaired functioning for 8 weeks. There is no bipolar history, psychosis, or substance misuse. She has not previously received treatment. According to CANMAT 2023 guidelines, what is an appropriate first-line pharmacologic treatment option for major depressive disorder?

Accepted Answer

A selective serotonin reuptake inhibitor (e.g., sertraline)

Answer

Diazepam

Answer

Tricyclic antidepressant as first-line in all patients

Answer

Antipsychotic monotherapy

Answer

St John's wort as first-line therapy

ca-mccqe1 MCQ (SBA): Major depressive disorder - first-line treatment