Heart Failure with Reduced Ejection Fraction (HFrEF) — EECC MCQ

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EasyC). Minoxidil/alpha-1 blockers lack outcome benefit (DHeart Failure with Reduced Ejection Fraction (HFrEF)EECC

A 68-year-old with HFrEF (EF 28%) on core therapies remains hypertensive. Which antihypertensive can be added with outcome benefit?

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Correct answer: B — Hydralazine-isosorbide dinitrate (especially if Black or ACEi/ARB intolerant)

Hydralazine-isosorbide dinitrate reduces mortality and hospitalizations, especially in Black patients or ACEi/ARB intolerance.

Reference: AHA/ACC/HFSA Guideline (2022): Management of Heart Failure. Non-dihydropyridine CCBs are harmful. Minoxidil/alpha-1 blockers lack outcome benefit.