A 58-year-old has ferritin 1,460 micrograms/L and transferrin saturation 78%. HFE testing shows C282Y homozygosity. Liver enzymes are mildly raised an...

Question

A 58-year-old has ferritin 1,460 micrograms/L and transferrin saturation 78%. HFE testing shows C282Y homozygosity. Liver enzymes are mildly raised and examination shows no stigmata of cirrhosis. Which additional assessment most directly determines the need for hepatocellular-carcinoma surveillance?

Accepted Answer

Stage liver fibrosis non-invasively, adding biopsy if unresolved

Answer

Repeat iron indices after initial venesection therapy

Answer

Measure myocardial iron using cardiac T2-star MRI

Answer

Quantify serum hepcidin before fibrosis assessment

Answer

Screen first-degree relatives before liver fibrosis assessment

Post-Discharge Thromboprophylaxis — MRCP Part 1 MCQ