A patient with HFrEF is switching from ramipril to sacubitril/valsartan. What minimum medicine-free interval is required after the last ramipril dose?...

Question

A patient with HFrEF is switching from ramipril to sacubitril/valsartan. What minimum medicine-free interval is required after the last ramipril dose?

Accepted Answer

Wait at least 36 hours before the first sacubitril/valsartan dose

Answer

Start sacubitril/valsartan with the final ramipril dose; after clinical assessment

Answer

Wait 6 hours before starting the replacement treatment; with monitoring

Answer

Continue both medicines together for one week; after clinical assessment

Answer

Wait 7 days after assessment of renal function and symptoms

Heart Failure with Reduced Ejection Fraction — MRCP Part 1 MCQ

A patient with HFrEF is switching from ramipril to sacubitril/valsartan. What minimum medicine-free interval is required after the last ramipril dose?