A 70-year-old with AF and prior stroke on apixaban presents with GI illness causing dehydration. Creatinine rises from 1.0 to 2.1 mg/dL (eGFR now 28)....

Question

A 70-year-old with AF and prior stroke on apixaban presents with GI illness causing dehydration. Creatinine rises from 1.0 to 2.1 mg/dL (eGFR now 28). What is the most appropriate action?

Accepted Answer

Assess renal function and consider temporary dose adjustment or hold if acute kidney injury is severe, then resume per labeling

Answer

Continue full dose without reassessment

Answer

Hold apixaban and switch to warfarin immediately

Answer

Stop anticoagulation permanently

Answer

Add aspirin

us-abim MCQ (SBA): AF (AKI and DOAC Management)

A 70-year-old with AF and prior stroke on apixaban presents with GI illness causing dehydration. Creatinine rises from 1.0 to 2.1 mg/dL (eGFR now 28). What is the most appropriate action?