Diabetes with CKD/ASCVD — SCE Endocrinology MCQ

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HardEndocrinologyDiabetes with CKD/ASCVDSCE Endocrinology

A newborn is found to carry the familial RET p.Met918Thr variant associated with MEN2B. What preventive management is required?

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Correct answer: E — Expert total thyroidectomy during the first year

RET p.Met918Thr confers the highest and earliest medullary-thyroid-carcinoma risk. Expert paediatric endocrine and surgical assessment should lead to prophylactic total thyroidectomy in the first year, while timing also considers the infant and excludes associated disease.

Reference: GeneReviews: multiple endocrine neoplasia type 2 (Current GeneReviews chapter, accessed 30 July 2026): https://www.ncbi.nlm.nih.gov/books/NBK1257/; NHS Genomics Education testing pathway for medullary thyroid carcinoma (Reviewed 7 January 2026): https://www.genomicseducation.hee.nhs.uk/genotes/in-the-clinic/presentation-patient-with-medullary-thyroid-carcinoma/