Syphilis (Primary) — Medical Practice MCQ

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EasyInfectious DiseasesSyphilis (Primary)

A 26-year-old with painless chancre (primary syphilis). RPR positive; no penicillin allergy. Preferred treatment?

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Correct answer: C — Benzathine penicillin G 2.4 million units IM once

Benzathine penicillin G 2.4 million units IM once is first-line for early syphilis. Doxycycline is an alternative if allergic. Ceftriaxone is not standard monotherapy. Azithromycin is not recommended due to resistance. Penicillin VK is not appropriate.

Reference: CDC Guideline (2021): Sexually Transmitted Infections Treatment Guidelines