A woman with previous immune TTP is asymptomatic but has repeatedly fallen ADAMTS13 activity during remission. She is not pregnant. Which pre-emptive ...

Question

A woman with previous immune TTP is asymptomatic but has repeatedly fallen ADAMTS13 activity during remission. She is not pregnant. Which pre-emptive intervention is supported to reduce relapse risk?

Accepted Answer

Pre-emptive rituximab under specialist monitoring

Answer

Prophylactic platelet transfusion at each outpatient review

Answer

Regular caplacizumab without concurrent disease monitoring

Answer

Long-term therapeutic plasma exchange every fortnight

Answer

Splenectomy before any clinical evidence of recurrence

Transfusion Strategy — MRCP Part 1 MCQ

A woman with previous immune TTP is asymptomatic but has repeatedly fallen ADAMTS13 activity during remission. She is not pregnant. Which pre-emptive intervention is supported to reduce relapse risk?