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Clostridioides difficile Infection — Medical Practice MCQ

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HardInfectious DiseasesClostridioides difficile Infection

An adult has a first non-severe episode of Clostridioides difficile infection. Which initial prescription follows NICE guidance?

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Correct answer: A — Oral vancomycin 125 mg four times daily for 10 days

NICE uses oral vancomycin for a first episode. For a second episode within 12 weeks of symptom resolution, fidaxomicin is preferred; later recurrence may use vancomycin or fidaxomicin with specialist input. Stop unnecessary precipitating antibiotics and reassess severity, hydration and surgical warning signs.

Reference: https://www.nice.org.uk/guidance/ng199