A woman has received denosumab 60 mg every six months for five years. She now needs to stop; eGFR is 72 mL/min/1.73 m² and calcium is normal. Which

Question

A woman has received denosumab 60 mg every six months for five years. She now needs to stop; eGFR is 72 mL/min/1.73 m² and calcium is normal. Which plan best limits rebound vertebral fractures?

Accepted Answer

Planned zoledronate infusion at six months with CTX-guided follow-up

Answer

Stop after the final injection and begin a two-year drug holiday

Answer

Start teriparatide alone when the next denosumab dose becomes due

Answer

Delay all antiresorptive treatment until DXA shows significant bone loss

Answer

Reduce denosumab to one injection every eighteen months before stopping

Osteoporosis Therapy — SCE Endocrinology MCQ

A woman has received denosumab 60 mg every six months for five years. She now needs to stop; eGFR is 72 mL/min/1.73 m² and calcium is normal. Which plan best limits rebound vertebral fractures?