A 58-year-old with suspected C. difficile colitis has ileus, leukocytosis 32,000/µL, and creatinine 2.6 mg/dL. Optimal initial therapy?...

Question

A 58-year-old with suspected C. difficile colitis has ileus, leukocytosis 32,000/µL, and creatinine 2.6 mg/dL. Optimal initial therapy?

Accepted Answer

Oral vancomycin 500 mg QID plus IV metronidazole 500 mg q8h (consider rectal vancomycin)

Answer

Fidaxomicin 200 mg BID only

Answer

Metronidazole monotherapy

Answer

Probiotics and loperamide

Answer

No antibiotics until culture returns

us-abem MCQ (SBA): C. difficile Infection