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C. difficile Infection — Medical Practice MCQ

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EasyInfectious DiseasesC. difficile Infection

A 24-year-old with watery diarrhea after clindamycin has a first episode of nonsevere C. difficile infection (WBC 9,000/µL, creatinine normal). Optimal initial therapy?

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Correct answer: B — Fidaxomicin 200 mg orally twice daily for 10 days

NICE and UKHSA/SHEA 2021 recommend fidaxomicin as preferred initial therapy; vancomycin is an acceptable alternative. Metronidazole is not preferred for initial nonsevere CDI; adding IV metronidazole is for fulminant disease; probiotics are not adequate therapy.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/infections