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CAP-Outpatient Regimen Selection — Medical Practice MCQ

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ModerateInfectious DiseasesCAP-Outpatient Regimen Selection

A 67-year-old with suspected CAP asks about macrolide monotherapy. Local macrolide resistance to S. pneumoniae is 30%. What do guidelines suggest for a healthy outpatient?

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Correct answer: B — Avoid macrolide monotherapy; use amoxicillin 1 g TID or doxycycline

For healthy outpatients, amoxicillin or doxycycline are recommended; macrolide monotherapy is acceptable only if local resistance <25%. Cephalexin (C) is not adequate; amox/clav plus macrolide (D) is for comorbidities; universal fluoroquinolone use (E) is discouraged.

Reference: ATS/IDSA Guideline (2019): Diagnosis and Treatment of Adults with Community-Acquired Pneumonia