Type 2 Diabetes-Initial Therapy — SCE Endocrinology MCQ

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ModerateEndocrinologyType 2 Diabetes-Initial TherapySCE Endocrinology

A 57-year-old man with T2DM (A1c 10.8%), polyuria, and weight loss seeks therapy. According to ADA Standards, what is the best initial pharmacotherapy?

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Correct answer: A — Initiate insulin therapy

Explanation lettering: D = shown as A · C = shown as B · A = shown as C · E = shown as D · B = shown as E

ADA Standards recommend initiating insulin for marked hyperglycemia (A1c ≥10% or symptomatic catabolism). Monotherapy with metformin (A), GLP-1 (B), or SGLT2 (C) is insufficient acutely; lifestyle alone (E) is inadequate.

Reference: ADA Standards of Care (2025): Standards of Medical Care in Diabetes