Gonorrhea — Medical Practice MCQ

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EasyInfectious DiseasesGonorrhea

A 23-year-old sexually active patient tests positive for uncomplicated urogenital gonorrhea. Weight 70 kg, not pregnant. Best empiric treatment?

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Correct answer: C — Ceftriaxone 1 g IM single dose

In current UK practice, uncomplicated urogenital gonorrhoea in a non-pregnant adult is treated first line with ceftriaxone 1 g intramuscularly as a single dose. This applies to uncomplicated ano-genital infection and is not reduced to 250 mg or 500 mg for a 70 kg adult under UK guidance. Cefixime alone is not preferred empiric therapy, and routine dual therapy with azithromycin plus low-dose ceftriaxone is outdated. The best answer is therefore ceftriaxone 1 g IM single dose.

Reference: British Association for Sexual Health and HIV (BASHH) National Guideline for the Management of Gonorrhoea, 2025: recommends ceftriaxone 1 g IM as a single dose for uncomplicated ano-genital and pharyngeal infection in adults. https://www.bashh.org/_userfiles/pages/files/gc_guideline_2025_final.pdf