H. pylori-Test of Cure — MRCGP AKT MCQ

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HardGastroenterologyH. pylori-Test of CureMRCGP AKT

A patient with a previous bleeding peptic ulcer completes Helicobacter pylori eradication therapy. Which test-of-cure plan is reliable?

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Correct answer: E — Delayed breath or stool test after PPI withdrawal

The best answer is “Delayed breath or stool test after PPI withdrawal”. A urea breath test or monoclonal stool antigen test is used after an adequate interval; antibiotics require at least a 4-week gap and a proton-pump inhibitor is withheld for 2 weeks to reduce false-negative results. Serology cannot distinguish active from past infection, and prior ulcer bleeding makes confirmation particularly important.

Reference: NICE CKS: Dyspepsia proven functional: https://cks.nice.org.uk/topics/dyspepsia-proven-functional/