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H. pylori infection — USMLE Step 2 CK MCQ

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MediumHelicobacter pylori TreatmentH. pylori infectionUSMLE Step 2 CK

A 50-year-old has persistent H. pylori after clarithromycin triple therapy. Next recommended regimen?

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Correct answer: B — Bismuth quadruple therapy for 14 days

After failure of clarithromycin triple therapy, ACG recommends optimized bismuth quadruple therapy for 14 days. Repeating the same regimen (A) is ineffective. Dual therapy (D) and monotherapy (E) are inadequate. Assuming false positive (C) is inappropriate without testing strategy.

Reference: https://www.ncbi.nlm.nih.gov/books/#stage-9-order-70