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Colorectal Cancer Screening — UKMLA MCQ

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A 35-year-old’s routine cervical sample is positive for high-risk HPV, but reflex cytology shows no abnormal cells. She has no symptoms, is not immunosuppressed and has no previous abnormal result. What should be arranged?

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Correct answer: B — Repeat HPV-based cervical screening in 12 months

The best answer is “Repeat HPV-based cervical screening in 12 months”. A first high-risk HPV-positive, cytology-negative screening result needs another HPV-based screening test in 12 months, not cytology alone at 6 months. Symptoms require clinical assessment rather than a repeat screening cytology test. Persistent high-risk HPV is managed through the subsequent repeat-screening and colposcopy pathway.

Reference: NHS: cervical screening results: https://www.nhs.uk/tests-and-treatments/cervical-screening/your-results/