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Primary Hypertension — USMLE Step 2 CK MCQ

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HardCardiologyPrimary HypertensionUSMLE Step 2 CK

A 47-year-old woman has an average home and office blood pressure of 134/82 mm Hg despite 4 months of sodium reduction, weight loss, and regular exercise. She has no diabetes, CKD, or clinical cardiovascular disease. Her 10-year PREVENT cardiovascular risk is 8.4%. What is the best next step?

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Reveal the answer and explanation

Correct answer: BBegin one first-line antihypertensive medication and continue lifestyle therapy

B is correct: current US guidance recommends medication plus lifestyle therapy for stage 1 hypertension when 10-year PREVENT cardiovascular risk is at least 7.5%. A uses the wrong threshold. C is preferred for stage 2 hypertension, not this modest elevation. D does not use a first-line class without another indication. E neither treats hypertension nor appropriately substitutes for antihypertensive therapy.

Reference: 2025 AHA/ACC high blood pressure guideline: top things to know. https://professional.heart.org/en/science-news/2025-high-blood-pressure-guideline/top-things-to-know