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Diabetic CKD with Albuminuria — ESENeph MCQ

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HardNephrologyDiabetic CKD with AlbuminuriaESENeph

A 62-year-old with CKD G3b (eGFR 32 mL/min/1.73 m²) and albuminuria A3 (UACR 400 mg/g) with diabetes is on maximally tolerated ACE inhibitor and an SGLT2 inhibitor. BP controlled, K⁺ 4.6 mEq/L. Next disease-modifying addition?

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Correct answer: DAdd nonsteroidal MRA (finerenone)

In diabetic CKD with persistent albuminuria despite ACEi/ARB and SGLT2 inhibition, adding a nonsteroidal MRA (finerenone) reduces kidney and CV events. Stopping ACEi (A) is harmful. Thiazide (B) or CCB (C) manage BP only. Loop diuretic (E) is for volume control, not disease modification.

Reference: Secondary Source: KDIGO (2024): Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease