A 29-year-old with chronic diarrhoea and iron deficiency is eating gluten daily. Coeliac disease is suspected, and no previous test suggests IgA defic...

Question

A 29-year-old with chronic diarrhoea and iron deficiency is eating gluten daily. Coeliac disease is suspected, and no previous test suggests IgA deficiency. Which initial serological request is most appropriate?

Accepted Answer

Measure total IgA and IgA tissue transglutaminase antibodies

Answer

Measure IgG tissue transglutaminase without total IgA

Answer

Measure IgA endomysial antibodies together with total IgA

Answer

Request HLA-DQ2 and HLA-DQ8 genotyping as initial testing

Answer

Measure IgG deamidated gliadin peptide and omit total IgA

NSTEMI — MRCP Part 1 MCQ

A 29-year-old with chronic diarrhoea and iron deficiency is eating gluten daily. Coeliac disease is suspected, and no previous test suggests IgA deficiency. Which initial serological request is most appropriate?