Hypercholesterolemia — USMLE Step 2 CK MCQ

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EasyCardiologyHypercholesterolemiaUSMLE Step 2 CK

A 28-year-old with LDL-C 205 mg/dL and no ASCVD presents for primary prevention. Best lipid therapy?

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Correct answer: B — High-intensity statin

Explanation lettering: C = shown as B · E = shown as C · B = shown as D · D = shown as E

LDL-C ≥190 mg/dL warrants high-intensity statin regardless of calculated risk. Lifestyle alone (A) is inadequate; moderate statin (B) under-treats; ezetimibe/PCSK9 alone (D,E) are not first-line in primary prevention absent statin intolerance.

Reference: ACC/AHA Guideline (2018): Blood Cholesterol Management