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HIV PEP — Medical Practice MCQ

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MediumInfectious DiseasesHIV PEP

A healthcare worker presents 24 hours after a high-risk occupational needle-stick from a source with unknown HIV status. HIV test is negative today. Best management?

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Correct answer: D — Start three-drug PEP for 28 days (e.g., TDF/FTC plus dolutegravir)

Explanation lettering: D = shown as A · E = shown as C · C = shown as D · A = shown as E

PEP should start as soon as possible (within 72 h) with a three-drug regimen for 28 days (e.g., TDF/FTC + an integrase inhibitor). A/E: Delay increases transmission risk. B: Insufficient duration and number of drugs. C: PrEP is not appropriate for postexposure management.

Reference: CDC Guideline (2023): Antiretroviral Postexposure Prophylaxis