Syphilis (Pregnancy) — USMLE Step 2 CK MCQ

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MediumInfectious DiseasesSyphilis (Pregnancy)USMLE Step 2 CK

A 32-year-old at 10 weeks' gestation is diagnosed with early syphilis. Best treatment?

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Correct answer: E — Benzathine penicillin G 2.4 million units IM single dose

Benzathine penicillin G is the treatment of choice for syphilis in pregnancy; alternatives are contraindicated or inferior. Doxycycline is contraindicated in pregnancy; azithromycin resistance is an issue; ceftriaxone is not first-line; delaying therapy risks fetal complications.

Reference: CDC (2021): STI Treatment Guidelines - Syphilis