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Graves’ Disease in Pregnancy — UKMLA MCQ

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HardEndocrinologyGraves’ Disease in PregnancyUKMLAMRCP Part 1MRCGP AKTPARAPSA

A pregnant woman taking propylthiouracil for Graves disease develops right-upper-quadrant pain, profound fatigue and jaundice. What is the immediate priority?

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Correct answer: A — Stop propylthiouracil and assess liver injury

The best answer is “Stop propylthiouracil and assess liver injury”. Propylthiouracil can cause severe hepatotoxicity. Symptoms suggesting liver injury require immediate cessation and urgent assessment, while thyroid control and pregnancy management are coordinated with specialists. Pregnancy-related liver disorders remain differentials but do not justify continued exposure to a potentially causative medicine.

Reference: Carbimazole 5 mg tablets Summary of Product Characteristics: https://www.medicines.org.uk/emc/product/14323/smpc