Pre-eclampsia Prevention — MRCGP AKT MCQ

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HardObstetrics & GynaecologyPre-eclampsia PreventionMRCGP AKT UKMLA PARA

A woman with chronic hypertension taking ramipril is planning pregnancy. What medicine change should be discussed before conception?

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Correct answer: A — Change to labetalol or nifedipine

The best answer is “Change to labetalol or nifedipine”. ACE inhibitors and ARBs are avoided in pregnancy because of fetal renal and other toxicity. Preconception review switches to a suitable agent such as labetalol, nifedipine or methyldopa according to individual factors while maintaining blood-pressure control.

Reference: NICE NG136: Hypertension in adults: https://www.nice.org.uk/guidance/ng136/chapter/Recommendations