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Panic Disorder — UKMLA MCQ

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HardPsychiatryPanic DisorderUKMLAMRCGP AKTPARAMRCP Part 1

A patient with genetically confirmed neuroferritinopathy has progressive orofacial dystonia and chorea. Which later MRI evolution is particularly characteristic of this FTL disorder?

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Correct answer: E — Putaminal and caudate cavitation after earlier iron deposition

The best answer is “Putaminal and caudate cavitation after earlier iron deposition”. Neuroferritinopathy initially produces susceptibility from iron in the globus pallidus, putamen, caudate, substantia nigra and related nuclei. With progression, cystic degeneration and cavitation of the putamen and caudate are particularly characteristic and help distinguish it within the NBIA differential. Isolated nigral signal is nonspecific, while pontine change, cortical diffusion restriction and calcification point toward different toxic, metabolic or degenerative processes.

Reference: Neuroferritinopathy — GeneReviews: https://www.ncbi.nlm.nih.gov/books/NBK1141/