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Hyperthyroidism — MRCGP AKT MCQ

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HardEndocrinologyHyperthyroidismMRCGP AKTUKMLAMRCP Part 1PARA

A patient taking carbimazole develops jaundice, dark urine and pale stools. What is the best action?

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Correct answer: AStop carbimazole and arrange urgent liver assessment

The best answer is “Stop carbimazole and arrange urgent liver assessment”. Carbimazole can cause serious hepatic injury. Jaundice, dark urine or pale stools require immediate withdrawal and urgent liver assessment; switching to another thionamide before defining the reaction may expose the patient to further harm.

Reference: Carbimazole 5 mg tablets Summary of Product Characteristics: https://www.medicines.org.uk/emc/product/14323/smpc